The van den Akker Lab

Our manuscript describing a novel γ-lactam PBP3 inhibitor that is effective against several MDR pathogens has been published online in Eur. J. Med. Chem.

4/29/21

https://pubmed.ncbi.nlm.nih.gov/33933754/

This work was in collaboration with Drs. Robert Bonomo and Mark Plummer.

Our manuscript describing a novel soluble guanylyl cyclase activator (Runcaciguat) has been published Online in J. Med. Chem.

4/20/20

https://pubmed.ncbi.nlm.nih.gov/33872507/

This work was in collaboration with Bayer AG, Pharmaceuticals

Our manuscript describing the Turnover Chemistry and Structural Characterization of a Lytic Transglycosylase of Campylobacter jejuni via crystallography, biophysical, and mass spectrometry methods was just published online

3/22/21

https://pubmed.ncbi.nlm.nih.gov/33749238/

This work was in collaboration with Drs. Shahriar Mobashery and Jun Lin.

Our manuscript describing the binding of the dual-target diazabicyclooctane inhibitors to the penicillin-binding protein 2 and 3 of the pathogen Pseudomonas aeruginosa via crystallography and biophysical methods was just published online

2/16/21

https://pubmed.ncbi.nlm.nih.gov/33593978/

This work was in collaboration with Wockhard Research Center and Dr. Robert Bonomo.

Our manuscript describing the microbiological, biochemical, and structural characterization of a γ-lactam siderophore PBP inhibitor was just published online

6/20/20

https://pubmed.ncbi.nlm.nih.gov/32420736/

This work was in collaboration with Drs. Robert Bonomo and Mark Plummer. Article featured on the Cover.

Congratulations to Snigdha and Ha for being accepted and entering into PhD programs and Radhika for being accepted and entering into Medical School!

7/1/20

Our manuscript describing the binding of the antibiotic ceftobiprole to the penicillin-binding protein 3 of the pathogen Pseudomonas aeruginos a via crystallography and biophysical methods was just published online

3/9/20

https://www.ncbi.nlm.nih.gov/pubmed/32152075

This work was in collaboration with Basilea Pharmaceutica International Ltd. and Dr. Robert Bonomo.

The lab receiving R21 NIH grant funding for a new project on fragment-based approaches to develop new inhibitors of lytic transglycosylases. Such inhibitors could potentiate β-lactam antibiotics.

12/30/19

The research of the van den Akker lab was recently featured in the annual research update of the Ohio Supercomputer Center.

12/1/19

https://www.osc.edu/sites/default/files/page-files/2019%20Research%20Report.pdf
This work featured an all-atom 1-μs molecular dynamics simulation of the doughnut-shaped lytic transglycosylase enzyme and its peptidoglycan substrate and was published last year.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197136

A multi-lab collaborative manuscript was accepted for publication entitled "A standard numbering scheme for class C β-lactamases".

11/8/19

https://aac.asm.org/content/early/2019/11/05/AAC.01841-19.long

A manuscript was accepted for publication on the crystal structure of doripenem in complex to a deacylation deficient mutant of the OXA-48 b-lactamase (collaboration with Dr. Papp-Wallace lab).

https://www.mdpi.com/2079-6382/8/3/145